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       XXVI Annual Congress of the Iranian Society of Ophthalmology        بـیــست و ششمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Quantitative Measurement of Vascular Density and Flow Using Optical Coherence Tomography Angiography in Patients with Uveitis Associated with Posterior Pole Vasculitis.
Author(s): ramak roohipour, Atta salabati, mohammad zarei, mohammad bagher rajabi, fatemeh bazvand, nazanin ebrahimi adib
Presentation Type: Oral
Subject: Posterior Segment and Uveitis
Others:
Presenting Author:
Name: Fatemeh Bazvand
Affiliation :(optional) TUMS
E mail: ft1_bazvand@yahoo.com
Phone:
Mobile: 09126179214
Purpose:

To evaluate the alternation of vascular structure and quantitative parameters including vascular density and flow separately in superficial capillary plexus, deep capillary plexus and choriocapillary level in patients with vasculitis and uveitis comparing with healthy control

Methods:

patients with simultaneous uveitis and vasculitis were recruited in this case control study and compared with healthy controls. Optical coherence tomography angiography (OCTA) was performed for all eyes.

Results:

38 eyes from 28 patients with mean age of 34.21 ± 14.85 years and 50 healthy subjects with mean age of 35.24 ± 9.86 years were included (p: 0.74). Flow in image scan 3×3 and 8×8 was significantly lower in vasculitis vs. control in 3 layers including superficial capillary network (1.139±0.318mm2 vs. 1.513±0.064mm2 and 10.348±2.765mm2 vs. 12.958±0.745mm2, p<0.001), deep capillary network (0.993±0.498mm2 vs. 1.592±0.083mm2 and 6.627±4.34mm2 vs. 12.775±1.506mm2, p<0.001) and choriocapillary (1.585±0.474mm2 vs. 1.971±0.036mm2 and 14.978±3.319mm2 vs. 17.738± 0.447mm2, p<0.001). Whole vascular density and parafoveal vascular density were significantly lower in both superficial (46.35±5.5% vs. 54.93±1.91% and 47.32±6.18% vs. 57.15±2.06%, p<0.001) and deep capillary plexuses (49.87±5.74% vs. 60.08±1.77% and 52.11±6.22% vs. 62.88±1.93%, p<0.001) comparison to control group. The most damaged parameter was flow in macula in deep capillary network. The combination of best model for distinguishes vasculitis from control group by using OCTA was -0.447*F 1mm choroid+75.82*VD parafovea deep (F1mmchoroid: Flow choriocapillary of circle with 1mm radius, VD parafovea deep: vascular density of parafovea in deep capillary network) with the threshold of 26.2 with AUC: 0.979, 95% lower: 0.948, sensitivity 0.98, specificity: 0.923, positive predictive value: 0.97, negative predictive value: 0.947 and accuracy: 0.964.

Conclusion:

OCTA can be used for diagnosis of vasculitis that may help us in early disgnosis and management of uveitis. The most involved layer in uveitis was deep capillary network however superficial and choriocapillary layers also were damaged.

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