|
مقاله
|
Abstract
|
|
|
|
Title:
|
Multipoint assessment of demarcation line depth after standard and accelerated CXL in central and peripheral keratoconus
|
|
Author(s):
|
Soheila Asgari PhD1, Hassan Hashemi MD2, Fedra Hajizadeh MD2, Mohammad Miraftab MD2, Mohammad Amin Seyedian MD2, Kazem Amanzadeh MD2, Ebrahim Jafarzadhpur PhD3, Shiva Mehravaran MD MIH4, Akbar Fotouhi
|
|
Presentation Type:
|
Oral
|
|
Subject:
|
Cornea and Anterior Segment
|
|
Others:
|
|
|
Presenting Author:
|
|
|
Name:
|
Hassan Hashemi
|
|
Affiliation :(optional)
|
Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;
|
|
E mail:
|
research@noorvision.com
|
|
Phone:
|
0
|
|
Mobile:
|
09121127421
|
|
|
|
|
Purpose:
|
To determine changes in the depth of the demarcation line in the central and peripheral cornea following accelerated 18 mW/cm2 compared to standard corneal cross-linking (CXL) in patients with progressive keratoconus, and the effect of cone position.
|
|
Methods:
|
In this matched prospective comparative study, 60 eyes with progressive keratoconus underwent CXL using accelerated or standard CXL (30 eyes in each group). AS-OCT imaging was done at 1 week and one month after the procedure to measure the depth of the demarcation line in the central cornea and on peripheral rings.
|
|
Results:
|
The depth of the demarcation line in the center was 266.5±67.5µm and 459.6±82.5µm in the accelerated and standard groups, respectively (P<0.001). The line depth significantly decreased from the center to the 7mm ring in the periphery in both groups (all P<0.05); this change was 7.99-17.72% in the accelerated group and 0.98%-9.52% in the standard group. In cases with central keratoconus, the line was significantly deeper in the standard group in the center and the 3mm ring (all P<0.05), but not all points on the 5mm and 7mm rings. In cases with an inferior cone, the line was significantly deeper at all studied points in the standard group (all P<0.001).
|
|
Conclusion:
|
The depth of the demarcation line with accelerated CXL is less than the standard protocol. Although line depth decreases from the center towards the periphery, corneal tissue reactions are more homogenized with standard CXL. In cases with central keratoconus, the peripheral effect may be similar with both protocols.
|
|
Attachment:
|
|
|
|