Pseudoexfoliation syndrome is an age-related disease which characterized with production and progressive accumulation Pseudoexfoliation is an ischemic disease and is associated with increased level of homocysteine. Related systemic diseases include transient ischemic attacks, hypertension, angina, myocardial and crebrovascular infarction, Alzheimer's disease and hearing loss. Considering this fact that in both pseudoexfoliation syndrome and some bone diseases such as osteoporosis the level of homocysteine is increased, so by doing this research, we decided to find out whether bone changing diseases such as osteoporosis as well as other mentioned diseases is associated with this syndrome or not?

This study is a case-control observational study. The study population included all patients admitted to Baghaee Poor hospital eye clinic in 2015. The group of cases includes 35 patients who were diagnosed as pseudoexfoliation syndrome . Control group also include 35 patients with no evidence of pseudoexfoliation syndrome. Patients in both groups underwent bone densitometry. All questionnaires were completed by one person as performer Physician. Finally, the results from the two groups were analyzed together.

The results showed a statistically significant difference between the mean lumbar spine bone mineral density in both groups including control group and the group of cases (p=0.002). So that the mean for spinal bone density in the group of cases was -2.57±0.36 and -1.48±0.02 in control group as well. More over, the results showed no significant relationship between age and sex with incidence of osteoporosis in patients with pseudoexfoliation syndrome (p>0.05).

According to a statistically significant relationship (p = 0.002) between the mean lumbar spine bone mineral density in both control and case groups, it can be concluded that the group of cases with pseudoexfoliation syndrome compared with controls who did not have the syndrome are at higher risk for developing osteoporosis.