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مقاله
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Abstract
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Title:
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Antioxidant enzymes levels in aqueous humour from Tunisian patients with glaucoma and cataract
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Author(s):
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Bouchemi Meryem1, Soualmia Hayet1*, Midani Fatma1, Bassem Hammami1, Feki Moncef1, El Afrit Ali2, Kaabachi Naziha1
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Presentation Type:
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Poster
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Subject:
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Glaucoma
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Others:
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Presenting Author:
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Name:
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Hayet Soualmia
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Affiliation :(optional)
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1University Tunis El Manar, Research Laboratory LR99ES11 La Rabta, 2Ophtalmology department, *High Institute Medical Technologies Tunis
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E mail:
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hayetsoualmia@yahoo.fr
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Phone:
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0021698206883
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Mobile:
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0021698206883
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Purpose:
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Oxidative stress plays a role in the pathogenesis of different ocular disorders. The aim of this study was to assess the levels of antioxidant enzymes such as the catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) in aqueous humour from Tunisian patients with primary open-angle glaucoma (POAG).
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Methods:
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Aqueous humour was obtained at time of surgery and analyzed for enzymatic activities of CAT, SOD and GPX by colorimetric method in 47 patients with POAG and 57 subjects with cataract.
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Results:
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The mean concentrations of CAT (U/ml) were 3.42± 0.24 in POAG patients and 5.09± 0.62 in cataract subjects; p<0.05. In addition, levels of SOD (U/ml) were 130.46± 9.25 vs 158.70± 7.83; p<0.04 in POAG and cataract groups respectively. Likewise, the GPX concentrations were significantly different between glaucoma patients and cataract subjects (14.22±1.66 vs 19.34 ± 2.13; p<0.05) respectively.
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Conclusion:
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The present study revealed that there was a decreased level of antioxidant enzymes in aqueous humour from a sample of Tunisian patients with POAG.
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Attachment:
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