Comparison of 1 mg and 4 mg Doses of Intravitreal Triamcinolone Acetonide in Macular Edema due to branch Retinal Vein Occlusion

16 eyes of 16 patients with macular edema due to branch retinal vein occlusion were randomized (8 eye in each group) to receive either 1 mg or 4 mg dose of intravitreal injection of triamcinolone acetonide. Each patient had a complete comprehensive ophthalmic examination Best-corrected visual acuity (BCVA) and intraocular pressure (IOP) Fundus fluorescein angiography and optical coherence tomography at baseline and at 1 month follow up.BCVA was measured in Snellen’s lines and converted into logarithm of minimum angle of resolution scale for statistical analysis. The data were statistically evaluated using t-tests. A P < 0.05 was considered significant.

There was no statistically significant difference in the mean foveal thickness measurement at baseline (P = 0.12) or at the 1 month (P =0.34) between both the groups. There was no statistically significant difference observed in mean BCVA between the two groups at 1 day and 1 month. There was no statistically significant difference observed in IOP between the two groups at 1 day, 1 week and 1 month.

The results of our study suggest that 1 mg dose of Intravitreal Triamcinolone Acetonide is as effective as 4 mg dose of IVTA in improving the functional and anatomical outcome in macular edema associated with branch retinal vein occlusions at 1 month follow up.