Review of the role of MicroRNA in diagnosis, prognosis and therapy of retinoblastoma

This review article focuses on a very important aspect of retinoblastoma (Rb) based on biomarker discovery covers the pros and cons of using miRNAs as important prognostics, diagnostics and therapeutics biomarkers for this life threatening disease. Rb is known as a rare form of cancer that rapidly develops from the immature cells of the retina. Prompt diagnosis and treatment are the cornerstones for the improvement of the Rb outcomes. Several lines of evidence have shown that the miRNAs can affect various pathologic events involved in the Rb.

The miRNAs regulate more than one hundred gene targets, on the other hand, one gene can also be regulated by a number of miRNAs. These molecules can serve as diagnostic, prognostic and therapeutic biomarkers in various stage of Rb

Here, we highlighted the state of the art for both discovered miRNAs as biomarkers and also future needs to ascertain if the use of miRNAs in combination with different systemic and conventional biomarkers and therapies would result in improved outcomes of retinoblastoma.