To report the spectrum of Vogt-Koyanagi-Harada disease in Iranian patients

Retrospective chart review of patients diagnosed with VKH disease at four referral centers in Iran. Patients' demographics, ocular and extraocular manifestations, treatment modalities, and complications were recorded. Patients were also classified as having either complete, incomplete, or probable VKH.

Eighty eight patients with a mean age of 32.1±12.6 years (range 7-79 years) were studied. Fifty nine patients (67.0%) were female. Sunset glow fundus was seen in 40.9% of eyes and nummular peripheral chorioretinal scars in 55.7% of eyes. Integumentary findings were reported by 14.8% of the patients. Immunomodulatory agents were used in 72.7% of the patients. Ocular complications occurred in 36.4% of eyes (mean follow up 3.8 years, range, 6–228 months). Final visual acuity was 20/40 or better in 73.3% of eyes. In patients with acute presentation, exudative retinal detachment was the most common ocular finding (87.8%) followed by optic disc swelling (71.4%). Anterior uveitis and vitritis, each were found in about half of the patients. Auditory symptoms were reported by 38.8% of the patients. Overall, 4 patients (4.5%) were classified as having complete type of the disease, 36 (40.9%) incomplete type, and 48 (54.5%) probable type.

In our series, there are clinical features that differ from those reported in other studies. Most patients exhibited the ‘probable’ type of VKH disease. The overall visual prognosis was favorable